21-Bromo-5alpha-pregnane-3,11,20-trione → 21-Morpholinoacetylthio-5alpha-pregnane-3,11,20-trione

HRID 1077024ノート

反応式

HRID 1077024 の反応式
Br[CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C:19](=[O:23])[CH2:20]2)[C@:16]2([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]2)[CH2:10][CH2:9]3)[CH2:6][CH2:5]1.[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]([OH:35])=[S:34])[CH2:28][CH2:27]1>CC(C)=O>[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]([S:34][CH2:2][C:3](=[O:25])[C@@H:4]2[C@:21]3([CH3:22])[C@H:7]([C@H:8]4[C@H:18]([C:19](=[O:23])[CH2:20]3)[C@:16]3([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]3)[CH2:10][CH2:9]4)[CH2:6][CH2:5]2)=[O:35])[CH2:28][CH2:27]1

参加物

4

反応物 2

HCID 8673347421-Bromo-5alpha-pregnane-3,11,20-trioneHCID 178526202HCID 178526202、化合物

生成物 1

HCID 8673347521-Morpholinoacetylthio-5alpha-pregnane-3,11,20-trione

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

21-Bromo-5α-pregnane-3,11,20-trione (1.04 g.) was refluxed in dry acetone (100 ml) with morpholino thioacetic acid (600 mg) for 15 minutes. The reaction mixture was concentrated, partitioned between ethyl acetate, water, pH 8, the organic layer was washed, dried (MgSO4) and evaporated to an off white solid (1.26g.)

後処理

  1. concentrationThe reaction mixture was concentrated
  2. custompartitioned between ethyl acetate, water, pH 8
  3. washthe organic layer was washed
  4. dry with materialdried (MgSO4)
  5. customevaporated to an off white solid (1.26g.)

出典と根拠

ORDレコード
ord-01fbc72acd6a4967b3bcd2a3737a6870
出典データセット
uspto-grants-1976_05
特許番号
US03959260

反応ノート

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