1-Hexanol → 3-Hexyloxypropylene glycol

HRID 1077097ノート

反応式

HRID 1077097 の反応式
C[O-].[Na+].[CH2:4]([OH:10])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C([O:15][CH2:16][CH:17]1[O:19][CH2:18]1)CCC.ClCl>CO.CCOCC>[CH2:4]([O:10][CH2:18][CH:17]([CH2:16][OH:15])[OH:19])[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

7

反応物 4

HCID 81031-HexanolHCID 17049Butyl glycidyl etherHCID 24526ChlorineHCID 10942334Sodium Methoxide

生成物 1

HCID 112290943-Hexyloxypropylene glycol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 3283Diethyl Ether溶媒

反応条件

温度
155 °C

実験手順

4.7g of a solution containing 22.7% sodium methylate in methanol is added to 61.2g of dehydrated n-hexanol. The methanol is eliminated by heating the mixture to 155°C. After cooling the mixture to 130°C, 39g of tertio-butyl-glycidyl-ether is introduced gradually over a two hour and 50 minute period. This ether has a boiling point of 87°-88°C under 88 mm of mercury and a purity of 95% as determined by measurement of the epoxide function. The secondary products which it contains are chlorinate derivatives having a chlorine content of 0.58%. The reaction is completed by heating the mixture at reflux for one hour.

後処理

  1. temperatureAfter cooling the mixture to 130°C
  2. temperatureby heating the mixture
  3. temperatureat reflux for one hour

出典と根拠

ORDレコード
ord-e05f6fd97ac4472a840aab8045840f8c
出典データセット
uspto-grants-1976_05
特許番号
US03959390

反応ノート

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