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Ammonia → (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| 反応物 | Lithium | HCID 3028194 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1-Methoxy-2-propanol | HCID 7900 | — |
| 生成物 | (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol | HCID 101950 | — |
反応手順
To 13β-ethyl-3-methoxy-gona-1,3,5(10)-trien-17β-ol (1.0 g.) in 1-methoxypropan-2-ol (100 cc.) add liquid ammonia (200 cc.), followed by lithium metal (1.2 g.) in small pieces with stirring. After discharge of the blue color add an excess ammonium chloride, followed by water; filter off the crude 13β-ethyl-3-methoxy-gona-2,5(10)-dien-17β-ol and dry, m.p. 98°-104°. No selective ultra-violet absorption beyond 220 mμ; infrared absorption peaks at 3.03, 5.92, 6.01 μ.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03959322 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-e3143b7af7464c89a6c753fe74b87862 |
| 出典メモ | uspto-grants-1976_05 |