(3S,6S)-Octane-3,6-diol → 2,3-bis[(2R,5R)-2,5-diethyl-phospholan-1-yl)-benzo[b]thiophene

反応式

[CH3:1][CH2:2][C@H:3](O)[CH2:4][CH2:5][C@@H:6](O)[CH2:7][CH3:8].[PH2:11][C:12]1[S:16][C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[C:13]=1[PH2:21]>>[CH2:2]([C@@H:3]1[CH2:4][CH2:5][C@@H:6]([CH2:7][CH3:8])[P:11]1[C:12]1[S:16][C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[C:13]=1[P:21]1[C@H:6]([CH2:7][CH3:8])[CH2:5][CH2:4][C@H:3]1[CH2:2][CH3:1])[CH3:1]

参加物

反応物 2

HCID 7009316(3S,6S)-Octane-3,6-diol

HCID 116584572,3-Bisphosphinobenzo[b]thiophene

生成物 1

HCID 865956202,3-bis[(2R,5R)-2,5-diethyl-phospholan-1-yl)-benzo[b]thiophene収率 48%

実験手順

In analogy to Example 11, the cyclic sulfate derived from (3S,6S)-3,6-octanediol is reacted with 2,3-bisphosphinobenzo[b]thiophene to give the title compound in 48% yield.

出典と根拠

ORDレコード: ord-c9e588b9fb2e4e3d96164ee2aa8ac6ed
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07094907B2

反応ノート

読み込み中…