化工社化工社 化学情報印刷レポート · 研究参考用
Levonorgestrel → 13beta-Ethyl-17alpha-vinyl-17beta-hydroxy-gon-4-en-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Levonorgestrel | HCID 13109 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium on calcium carbonate | HCID 17803853 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 13beta-Ethyl-17alpha-vinyl-17beta-hydroxy-gon-4-en-3-one | HCID 68144430 | — |
反応手順
Shake 13β-ethyl-17α-ethynyl-17β-hydroxy-gon-4-en-3-one (0.5 g.) in pyridine (20 cc.) containing a 2% palladium-calcium carbonate catalyst (150 mg.) with hydrogen at atmospheric pressure until one molecular equivalent of hydrogen has been absorbed. Recrystallise the product twice from ether-hexane and dry for 4 hours at 65°/.005 mm. to yield the title compound, m.p. 108°-111°; ultraviolet absorption peak at 240 (ε15,200); infrared absorption peak at 10.9μ.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03959322 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-2bfafe85a2b14c1c8c16967bb29f98ca |
| 出典メモ | uspto-grants-1976_05 |