化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 17beta-Allyloxy-13-ethyl-3-methoxygona-1,3,5(10)-triene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 17beta-Allyloxy-13-ethyl-3-methoxygona-1,3,5(10)-triene | HCID 86733492 | — |
反応手順
Reflux a suspension of 5.0 g. of dl-13-ethyl-3-methoxygona-1,3,5(10)-triene-17β-ol, 100 mg. of xylene, and 3.9 g. of sodium hydride (50% in mineral oil) for 1.5 hours. Add 14.5 ml. of allyl bromide and reflux for 22 hours. Make the reaction mixture acidic with dilute hydrochloric acid and extract the organic layer with sodium bicarbonate solution. Chromatograph the residue on alumina (Grade I neutral) in hexane and eluate the product with ether to obtain dl-17β-allyloxy-13-ethyl-3-methoxygona-1,3,5(10)-triene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03959322 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-db1a331c08994f5382dc45e5bb1d0a9b |
| 出典メモ | uspto-grants-1976_05 |