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Hydrochloric Acid → 13-Ethyl-17beta-(2-dimethylaminoethoxy)-3-methoxygona-1,3,5(10)-triene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium amide | HCID 24533 | — |
| 反応物 | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| 反応物 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 13-Ethyl-17beta-(2-dimethylaminoethoxy)-3-methoxygona-1,3,5(10)-triene | HCID 68143163 | — |
反応手順
Stir a solution of 860 mg. of sodium amide in 15 ml. of benzene and add 3.0 g. of dl-13-ethyl-3-methoxygona-1,3,5(10)-trien-17β-ol in 15 ml. of benzene. Heat for 2 hours at 70°-83°. Cool to room temperature and add 1.58 g. of N,N-dimethylamino-2-chloroethane hydrochloride and reflux for 16 hours. Pour over ice and acidify reaction mixture with 2 N hydrochloric acid. Extract with ether and basify the aqueous layer with 15% sodium hydroxide. Isolate material with ether. Evaporate the ether to obtain dl-13-ethyl-17β-(2-dimethylaminoethoxy)-3-methoxygona-1,3,5(10)-triene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03959322 |
| 出典データセット | uspto-grants-1976_05 |
| ORD ID | ord-804e56982a2a4808889991d28281b950 |
| 出典メモ | uspto-grants-1976_05 |