7-Dehydrocholesterol → Previtamin D3

HRID 1077380

反応式

HRID 1077380 の反応式
[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][C@@H:16]3[C@@:21]4([CH3:27])[CH2:22][CH2:23][C@H:24]([OH:26])[CH2:25][C:20]4=[CH:19][CH:18]=[C:17]3[C@@H:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7]>CCCCCC>[CH3:27][C:21]1[CH2:22][CH2:23][C@H:24]([OH:26])[CH2:25][C:20]=1/[CH:19]=[CH:18]\[C:17]1[C@@H:12]2[CH2:11][CH2:10][C@H:9]([C@@H:2]([CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7])[CH3:1])[C@@:13]2([CH3:28])[CH2:14][CH2:15][CH:16]=1

参加物

3

反応物 1

HCID 4394237-Dehydrocholesterol

生成物 1

HCID 5281058Previtamin D3

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

From the hexane data, it was concluded that the material eluted at 12.2 min is tachysterol. The size and kind of microreactor is important to the ratio of products formed. Where the microreactor is several times the size of the 7-DHC, the undesirable side reactions are more favored. For example the silica with 60 Å pores (Ex. 10 and 11) give a ratio of previtamin D3 :tachysterol similar to that of the reaction in hexane (Ex. 9). In micelles (Ex. 16), however, which form a similarly sized microreactor, but with an environment similar to that of a hydrocarbon solvent, tachysterol is very heavily favored.

後処理

  1. washeluted at 12.2 min
  2. customformed

出典と根拠

ORDレコード
ord-f6bb1851d396499fbfe04619d81b2ea2
出典データセット
uspto-grants-1996_08
特許番号
US05543016

関連ノート

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