Dicyclohexylcarbodiimide → 2-(Pyrrolidin-1-yl)pyridine

HRID 1077381

反応式

HRID 1077381 の反応式
C(O[C@H]1C[C@@H](O)C=C1)(=O)C.[CH2:11]1[CH2:16][CH2:15][CH:14]([N:17]=[C:18]=[N:19][CH:20]2[CH2:25][CH2:24][CH2:23]CC2)CC1>C(Cl)Cl>[N:19]1([C:18]2[CH:11]=[CH:16][CH:15]=[CH:14][N:17]=2)[CH2:20][CH2:25][CH2:24][CH2:23]1

参加物

4

反応物 2

HCID 10868DicyclohexylcarbodiimideHCID 98554984-Cyclopentene-1,3-diol, 1-acetate, (1R,3S)-rel-

生成物 1

HCID 110190202-(Pyrrolidin-1-yl)pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3.1 mmol of the cyclopentenol, 3.1 mmol of DCC and 0.1 mmol of PP are dissolved in CH2Cl2 in a 100 ml flask fitted with a CaCl2 tube, 3.1 mmol of the carboxylic acid are added at 0°-5° C. with ice cooling, and the mixture is stirred at room temperature for 24 hours. The precipitated urea is filtered off, the solvent is removed by evaporation, and the crude product is recrystallized a number of times from ethanol.

後処理

  1. customfitted with a CaCl2 tube
  2. filtrationThe precipitated urea is filtered off
  3. customthe solvent is removed by evaporation
  4. customthe crude product is recrystallized a number of times from ethanol

出典と根拠

ORDレコード
ord-6af82f90d71247dcb7e0ca8bd70bc64b
出典データセット
uspto-grants-1996_08
特許番号
US05543076

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