5,6-Diamino-1,3-dimethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-(2-(2,5-dimethyl-4-methoxyphenyl)ethenyl)-, (E)-

HRID 1077492

反応式

HRID 1077492 の反応式
[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=1[NH2:8].[CH3:13][O:14][C:15]1[C:25]([CH3:26])=[CH:24][C:18]([CH:19]=[CH:20][C:21](O)=O)=[C:17]([CH3:27])[CH:16]=1>>[CH3:13][O:14][C:15]1[C:25]([CH3:26])=[CH:24][C:18](/[CH:19]=[CH:20]/[C:21]2[NH:1][C:2]3[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=3[N:8]=2)=[C:17]([CH3:27])[CH:16]=1

参加物

3

反応物 2

HCID 795015,6-Diamino-1,3-dimethyluracilHCID 51998984-Methoxy-2,5-dimethylcinnamic acid

生成物 1

HCID 64489771H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-(2-(2,5-dimethyl-4-methoxyphenyl)ethenyl)-, (E)-収率 20%

実験手順

Substantially the same procedure as in Reference Example 70 was repeated using 1.0 g (5.88 mmol) of 5,6-diamino-1,3-dimethyluracil and 1.33 g (6.45 mmol) of 4-methoxy-2,5-dimethylcinnamic acid. Then, the resultant crude crystals were recrystallized from dimethylformamide to give 393 mg (yield 20%) of Compound 101 as pale yellow grains.

後処理

  1. customThen, the resultant crude crystals were recrystallized from dimethylformamide

出典と根拠

ORDレコード
ord-c63a778b940443f6b736e9107aca4b8c
出典データセット
uspto-grants-1996_08
特許番号
US05543415

関連ノート

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