3-(6-Bromo-1,3-benzodioxol-5-yl)acrylic acid → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(6-bromo-1,3-benzodioxol-5-yl)ethenyl)-1,3-diethyl-, (E)-

HRID 1077523ノート

反応式

HRID 1077523 の反応式
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[Br:15][C:16]1[CH:26]=[C:25]2[O:27][CH2:28][O:29][C:24]2=[CH:23][C:17]=1[CH:18]=[CH:19][C:20](O)=O>>[Br:15][C:16]1[CH:26]=[C:25]2[O:27][CH2:28][O:29][C:24]2=[CH:23][C:17]=1/[CH:18]=[CH:19]/[C:20]1[NH:1][C:2]2[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=2[N:8]=1

参加物

3

反応物 2

HCID 6056363-(6-Bromo-1,3-benzodioxol-5-yl)acrylic acidHCID 45721335,6-Diamino-1,3-diethyluracil

生成物 1

HCID 64489341H-Purine-2,6-dione, 3,7-dihydro-8-(2-(6-bromo-1,3-benzodioxol-5-yl)ethenyl)-1,3-diethyl-, (E)-収率 38%

実験手順

Substantially the same procedure as in Reference Example 70 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 3.77 g (13.9 mmol) of 2-bromo-4,5-methylenedioxycinnamic acid. Then, the resultant crude crystals were recrystallized from dimethylsulfoxide/water to give 2.01 g (yield 38%) of Compound 165 as a yellow powder.

後処理

  1. customThen, the resultant crude crystals were recrystallized from dimethylsulfoxide/water

出典と根拠

ORDレコード
ord-f933532924444825b895a0e77547cdb9
出典データセット
uspto-grants-1996_08
特許番号
US05543415

反応ノート

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