Acetic Anhydride → 2-(benzenesulfonyl)-3-ethoxyprop-2-enenitrile
反応式
[C:1]1([S:7]([CH2:10][C:11]#[N:12])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:13](OCC)(OCC)[O:14][CH2:15][CH3:16].C(OC(=O)C)(=O)C.C(OCC)(=O)C>CO>[CH2:15]([O:14][CH:13]=[C:10]([S:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:8])=[O:9])[C:11]#[N:12])[CH3:16]参加物
6
実験手順
A solution of (phenylsulfonyl)acetonitrile (10.5 g, 0.089 mol) in triethyl orthoformate (21 mL, 0.14 mol) and acetic anhydride (21 mL, 0.2 mol) was heated at 160° C. with removal of ethyl acetate (35 mL). The dark oily residue was dissolved in methanol (60 mL) and the solution was concentrated and recrystallized from hexanes/ethyl acetate to yield (11.98 g, 78%) of the desired product.
後処理
- concentrationthe solution was concentrated
- customrecrystallized from hexanes/ethyl acetate
出典と根拠
- ORDレコード
- ord-89762a37df2941d59d2cc293b7d3df3f
- 出典データセット
- uspto-grants-1996_08
- 特許番号
- US05545515
反応ノート
読み込み中…