Diethyl Ether → 4-Bromomethyl-2-(4-trifluoromethylphenyl)pyrimidine
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1.[Br:18]Br.CCOCC>C(O)(=O)C>[Br:18][CH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:13]=2)[N:3]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
A mixture of 4-methyl-2-(4-trifluoromethylphenyl)pyrimidine (3 g) and bromine (2.11 g) in 20 ml of acetic acid was warmed to 80° C. for 1 hour, and then allowed to cool to room temperature. Ether (10 ml) was added, and the precipitate filtered off and washed with ether, giving 3.3 g of 4-bromomethyl-2-(4-trifluoromethylphenyl)pyrimidine, m.p. 125° C.
後処理
- temperatureto cool to room temperature
- filtrationthe precipitate filtered off
- washwashed with ether
出典と根拠
- ORDレコード
- ord-93fa57582c3d46b0bb5396dc27aaf8b7
- 出典データセット
- uspto-grants-1996_08
- 特許番号
- US05545645
反応ノート
読み込み中…