N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

HRID 1077893ノート

反応式

HRID 1077893 の反応式
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])=[O:8])C>CO.O.Cl>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[N:9]1[CH:4]=[CH:5][NH:6][C:7]1=[O:8]

参加物

5

反応物 1

HCID 19065111N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea

生成物 1

HCID 190650921-(2,4-difluorophenyl)-2(1H,3H)-imidazolone収率 89.4%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

This urea compound (37.5 g) was dissolved in a mixture of 560 ml of methanol and 280 ml of water, 300 ml of 0.48M hydrochloric acid was added thereto and the mixture was stirred at room temperature for three days. The reaction solution was concentrated under reduced pressure and the crystals separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2-(1H,3H)-imidazolone as a colorless powder.

後処理

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe crystals separated out
  4. washwere washed with a mixture of water and methanol (5:1)

出典と根拠

ORDレコード
ord-fd1afeae18914c18ad6669ea4a3ee72f
出典データセット
uspto-grants-1996_08
特許番号
US05545652

反応ノート

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