1,2-Dichloro-4-nitrobenzene → 2-Chloro-1-fluoro-4-nitrobenzene

HRID 1078054ノート

反応式

HRID 1078054 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1Cl.[F-:12].[K+]>[Cl-].C([N+](CCCCCCCCCCCCCCCCCC)(C)C)CCCCCCCCCCCCCCCCC>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:12]

参加物

4

反応物 2

HCID 74431,2-Dichloro-4-nitrobenzeneHCID 522689Potassium Fluoride

生成物 1

HCID 676882-Chloro-1-fluoro-4-nitrobenzene収率 69%

試薬・触媒・溶媒 1

HCID 7879Distearyldimethylammonium chloride触媒

実験手順

576 g (3 mol) of 3,4-dichloronitrobenzene, 58 g (0.1 mol) of distearyldimethylammonium chloride and 139 g (2.4 mol) of potassium fluoride were reacted analogously to Example 1. After filtering with suction, the residue was dissolved in water, the organic phase was separated off and the combined organic phases were fractionated. 289 g (69%, relative to potassium fluoride employed) of 3-chloro-4-fluoronitrobenzene were obtained.

後処理

  1. filtrationAfter filtering with suction
  2. dissolutionthe residue was dissolved in water
  3. customthe organic phase was separated off

出典と根拠

ORDレコード
ord-e30add03b270414caea64b94a829809e
出典データセット
uspto-grants-1996_08
特許番号
US05545768

反応ノート

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