2'-[(t-Butoxycarbonylamino)methyl]-1,1-biphenyl-4-methanol → 4(R)-Benzyloxycarbonylamino-2,3,4,5-tetrahydro-2-[[2'-[[(t-butoxycarbonyl)amino]methyl][1,1'-biphenyl]-4-yl]-methyl]-1H-2-benzazepin-3-one

関与物質

反応手順

Prepared from 4(R)-benzyloxycarbonylamino-2,3,4,5-tetrahydro-1H-2-benzazepin-3-one (Step H) and 2'-[(t-butoxycarbonylamino)methyl]-1,1'-biphenyl-4-methanol, methanesulfonate ester (Step F) by the procedure described in Example 1, Step E. 1H NMR (400 MHz, CDCl3): δ1.40 (s, 9H), 3.02 (dd; 12, 16 Hz; 1H), 3.55 (dd; 5, 16 Hz; 1H), 3.87 (d, 18 Hz, 1H), 4.18 (d, 6 Hz, 2H), 4.43 (d, 15 Hz, 1H), 4.60 (br t, 6 Hz, 1H), 4.95 (d, 15 Hz, 1H), 5.07 (d, 18 Hz, 1H), 5.13 (s, 2H), 5.29 (dd; 5, 12 Hz; 1H), 6.25 (d, 6 Hz, 1H), 6.87 (d, 8 Hz, 1H), 7.04 (t, 8 Hz, 1H), 7.10 (d, 8 Hz, 1H), 7.13-7.45 (m, 14 H). FAB-MS: calculated for C37H39N3O5 605; found 612 (M+Li,100%).

情報源と証拠