Dimethylamine → HCID 67667357、化合物

HRID 1078202ノート

反応式

HRID 1078202 の反応式
Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6](Cl)[N:5]=[C:4]([CH3:14])[N:3]=1.C(C1C=C(O)C=CC=1)(C)C.C(=O)([O-])[O-].[K+].[K+].[CH3:31][NH:32][CH3:33]>CN(C)C=O.O>[CH3:31][N:32]([CH3:33])[N:5]1[CH:6]=[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:2]=[N:3][CH:4]1[CH3:14]

参加物

7

反応物 4

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 120593-IsopropylphenolHCID 19071353HCID 19071353、化合物

生成物 1

HCID 67667357HCID 67667357、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Methyl 4,6-dichloro-2-methyl-pyrimidin-5-yl-acetate (23.5 g, 0.1 mol), 3-isopropylphenol (13.6 g, 0.1 mol) and potassium carbonate (20.7 g, 0.15 mol) are heated in dimethylformamide (30 ml) at 100° C. for 45 minutes. The mixture is cooled and an aqueous solution of dimethylamine (50 ml of a 40% solution) is added. Stirring is continued for 16 hours at room temperature. Addition of water, filtering and drying gives the methyl 1-dimethylamino-2-methyl-pyrimidin-5-yl-acetate as a brownish solid (28 g).

後処理

  1. temperatureThe mixture is cooled
  2. filtrationfiltering
  3. customdrying

出典と根拠

ORDレコード
ord-8a9b491af12544f1bbc6457fbed3f3f3
出典データセット
uspto-grants-1996_08
特許番号
US05547919

反応ノート

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