m-Anisoyl chloride → 3-Methoxybenzamide

HRID 1078362ノート

反応式

HRID 1078362 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].C([O-])(=O)C.[NH4+:16]>CC(C)=O.ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH2:16])=[O:7]

参加物

5

反応物 2

HCID 74374m-Anisoyl chlorideHCID 517165Ammonium Acetate

生成物 1

HCID 984873-Methoxybenzamide収率 49.8%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6344Dichloromethane溶媒

実験手順

17 g of 3-methoxybenzoyl chloride were dissolved in 200 ml acetone. 15.5 g of ammonium acetate were added to the solution and the reaction mixture was stirred for several hours at room temperature. Then it was dissolved in dichloromethane. The dichloromethane phase was dried by adding sodium carbonate and concentrated. 7.5 g of 3-methoxybenzamide were obtained as a colorless solid.

後処理

  1. dry with materialThe dichloromethane phase was dried
  2. additionby adding sodium carbonate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-228169d585f3459db6433751facf9e90
出典データセット
uspto-grants-1996_08
特許番号
US05547967

反応ノート

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