Sulfuryl chloride → (2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide

HRID 1078478

反応式

HRID 1078478 の反応式
[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:5]/[O:6][CH3:7].S(Cl)([Cl:25])(=O)=O>ClCCl.O>[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[CH:17][C:18]([Cl:25])=[CH:19][CH:20]=1)=[N:5]/[O:6][CH3:7]

参加物

5

反応物 2

HCID 24648Sulfuryl chlorideHCID 5483872(2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamide

生成物 1

HCID 19429863(2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide収率 68.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of (E)-N-methyl-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (500 mg) in dichloromethane was cooled to 0° C., and sulfuryl chloride (285 mg) was dropwise added thereto. The resultant mixture was stirred at the same temperature for 2 hours, diluted with water and extracted with diethyl ether. The solvent was dried and removed, and the residue was subjected to HPLC with a mixture of hexane and ethyl acetate to give 382 mg of the objective compound.

後処理

  1. extractionextracted with diethyl ether
  2. customThe solvent was dried
  3. customremoved
  4. additionthe residue was subjected to HPLC with a mixture of hexane and ethyl acetate

出典と根拠

ORDレコード
ord-0e14e4fae84e4d0694823c9fa2d761c5
出典データセット
uspto-grants-1996_08
特許番号
US05548078

関連ノート

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