tert-BUTYL CHLORIDE → (2E)-2-[2-(4-tert-butylphenoxy)phenyl]-2-methoxyimino-N-methylacetamide

HRID 1078480

反応式

HRID 1078480 の反応式
[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:5]/[O:6][CH3:7].[Cl-].[Al+3].[Cl-].[Cl-].[C:26](Cl)([CH3:29])([CH3:28])[CH3:27]>[N+](C)([O-])=O.O>[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[CH:17][C:18]([C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:19][CH:20]=1)=[N:5]/[O:6][CH3:7]

参加物

6

反応物 3

HCID 10486tert-BUTYL CHLORIDEHCID 5483872(2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 76327444(2E)-2-[2-(4-tert-butylphenoxy)phenyl]-2-methoxyimino-N-methylacetamide収率 104.4%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6375Nitromethane溶媒

実験手順

To a solution of (E)-N-methyl-2-(2-phenoxyphenyl)2-methoxyiminoacetamide (300 mg) in nitromethane (3 ml), aluminium chloride (423 mg) and t-butyl chloride (147 mg) were added, followed by stirring at room temperature for 1 hour. The reaction mixture was diluted with water and extracted with diethyl ether. The solvent was dried and evaporated, and the residue was purified by silica gel column chromatography with a mixture of hexane and ethyl acetate to give 375 mg of the objective compound.

後処理

  1. extractionextracted with diethyl ether
  2. customThe solvent was dried
  3. customevaporated
  4. customthe residue was purified by silica gel column chromatography with a mixture of hexane and ethyl acetate

出典と根拠

ORDレコード
ord-d9f7ce61bbf54e8087207362cccb1314
出典データセット
uspto-grants-1996_08
特許番号
US05548078

関連ノート

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