4'-Hydroxyacetophenone → 2-Bromo-1-(4-hydroxyphenyl)ethanone

HRID 10787

反応式

HRID 10787 の反応式
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=[O:3].[Br:11]Br>O1CCOCC1>[Br:11][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)=[O:3]

参加物

4

反応物 2

HCID 74694'-HydroxyacetophenoneHCID 24408Bromine

生成物 1

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanone収率 44%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of 4-hydroxyacetophenone (2.5 g, 18.3 mmol) (Aldrich) in dioxane (10 mL) was added dropwise a solution of bromine (3.22 g, 20.1 mmol) in dioxane (20 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was recrystalized from methanol to provide 2-bromo-1-(4-hydroxyphenyl)ethanone (1.73 g, 44% yield).

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was recrystalized from methanol

出典と根拠

ORDレコード
ord-1467451901b34110b095a0f9bc4d4385
出典データセット
uspto-grants-2006_08
特許番号
US07094896B2

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