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(RS)-Salsolinol → alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dihydroxy-1-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline-pentanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (RS)-Salsolinol | HCID 54456 | — |
| 反応物 | alpha-(3-Chloropropyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)-thio]benzeneacetonitrile | HCID 10738259 | — |
| 生成物 | alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dihydroxy-1-methyl-alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline-pentanenitrile | HCID 10839653 | 18.3% |
反応手順
The procedure of Example 3 is repeated using 1.0 g of α-(3-chloropropyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 0.76 g of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline. This affords 0.253 g of the desired product as a beige gum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05550149 |
| 出典データセット | uspto-grants-1996_08 |
| ORD ID | ord-84fb6fc2588d4b65b1c01733fbea9f0d |
| 出典メモ | uspto-grants-1996_08 |