Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

1. concentrationthe mixture was concentrated in vacuo
2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

ORDレコード

ord-b766bbeecace419eaa52b615ff7cd9e8

出典データセット

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07094896B2