Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

HRID 10789

反応式

HRID 10789 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:11]

参加物

4

反応物 2

HCID 24408BromineHCID 5185963',5'-Difluoroacetophenone

生成物 1

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanone収率 64.3%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

出典と根拠

ORDレコード
ord-b766bbeecace419eaa52b615ff7cd9e8
出典データセット
uspto-grants-2006_08
特許番号
US07094896B2

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