Hydrochloric Acid → (R-(R*,R*))-3-((o-Aminophenyl)thio)-3-(p-methoxyphenyl)lactic acid

HRID 1079301

反応式

HRID 1079301 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C@H:9]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)[C@H:10]([OH:14])[C:11]([O-:13])=[O:12].C[C@H]([NH3+])C1C=CC=CC=1.Cl>O>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C@H:9]([C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[C@H:10]([OH:14])[C:11]([OH:13])=[O:12]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86750040HCID 86750040、化合物

生成物 1

HCID 6451870(R-(R*,R*))-3-((o-Aminophenyl)thio)-3-(p-methoxyphenyl)lactic acid収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Dissolve the (-)-salt 4 (42.85 g, 97.26 mmol) in boiling water (430 mL). Add hot 1N HCl (98 mL). Reflux for 1 min. Cool the mixture in an ice-water bath and stir vigourously to precipitate. Check (and adjust if necessary) the pH of the solution to 5.0 (pH meter). Collect the solid by filtration. Wash with water and dry in vacuo at 40° C. to obtain the title compound 5 (24.85 g, 80%). m.p. 175°-176° C. [α]D23 -362.8° (1.2 DMF).

後処理

  1. temperatureReflux for 1 min
  2. temperatureCool the mixture in an ice-water bath
  3. customto precipitate
  4. customCollect the solid
  5. filtrationby filtration
  6. washWash with water
  7. customdry in vacuo at 40° C.

出典と根拠

ORDレコード
ord-91f5817949094ac49a86750469c7a62c
出典データセット
uspto-grants-1996_12
特許番号
US05580867

関連ノート

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