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Hydrochloric Acid → (R-(R*,R*))-3-((o-Aminophenyl)thio)-3-(p-methoxyphenyl)lactic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (S)-alpha-Methylbenzylammonium (2R,3R)-3-[(aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl) propionate | HCID 86750040 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (R-(R*,R*))-3-((o-Aminophenyl)thio)-3-(p-methoxyphenyl)lactic acid | HCID 6451870 | 80% |
反応手順
Dissolve the (-)-salt 4 (42.85 g, 97.26 mmol) in boiling water (430 mL). Add hot 1N HCl (98 mL). Reflux for 1 min. Cool the mixture in an ice-water bath and stir vigourously to precipitate. Check (and adjust if necessary) the pH of the solution to 5.0 (pH meter). Collect the solid by filtration. Wash with water and dry in vacuo at 40° C. to obtain the title compound 5 (24.85 g, 80%). m.p. 175°-176° C. [α]D23 -362.8° (1.2 DMF).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05580867 |
| 出典データセット | uspto-grants-1996_12 |
| ORD ID | ord-91f5817949094ac49a86750469c7a62c |
| 出典メモ | uspto-grants-1996_12 |