Acetyl chloride → N-(4-(1-Piperidinyl)phenyl)acetamide

HRID 1079394ノート

反応式

HRID 1079394 の反応式
Cl.Cl.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:23](Cl)(=[O:25])[CH3:24]>O>[C:23]([NH:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1)(=[O:25])[CH3:24]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 233669404-(Piperidin-1-yl)aniline dihydrochloride

生成物 1

HCID 732499N-(4-(1-Piperidinyl)phenyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of N-(4-aminophenyl)piperidine dihydrochloride (2.49 g) and triethylamine (5.6 g) in dichloroform (30 ml) was ice-cooled and to this was added dropwise acetyl chloride (1.42 ml). After stirred at room temperature for 30 minutes, water (10 ml) was added to the mixture and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off and then the residue was recrystallized from ethyl ether to obtain N(4-acetylaminophenyl)piperidine (2 g) as colorless crystals, m.p. 150°-152° C.

後処理

  1. temperaturecooled
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. distillationThe solvent was distilled off
  4. customthe residue was recrystallized from ethyl ether

出典と根拠

ORDレコード
ord-45b0e8bf45724a65aa6aa2fdba130a55
出典データセット
uspto-grants-1996_12
特許番号
US05580883

反応ノート

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