Hydrochloric Acid → 4-(2-Methyl-4-nitrophenoxy)piperidine--hydrogen chloride (1/1)

HRID 1079401ノート

反応式

HRID 1079401 の反応式
C([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=2[CH3:20])[CH2:6][CH2:5]1)(=O)C.[ClH:21].C(O)C>O>[ClH:21].[N+:17]([C:14]1[CH:15]=[CH:16][C:11]([O:10][CH:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[C:12]([CH3:20])[CH:13]=1)([O-:19])=[O:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 23366939HCID 23366939、化合物

生成物 1

HCID 233669804-(2-Methyl-4-nitrophenoxy)piperidine--hydrogen chloride (1/1)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 1-acetyl-4-(4-nitro-2-methylphenyloxy)piperidine (11.8 g) were added conc. hydrochloric acid (15 ml), ethanol (15 ml) and water (15 ml) and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, the residue thus obtained was washed with ethyl ether and crystals were filtered off to obtain 4-(4-nitro-2-methylphenyloxy)piperidine hydrochloride (8.3 g) as white crystals, m.p. 204°-226° C.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue thus obtained
  5. washwas washed with ethyl ether and crystals
  6. filtrationwere filtered off

出典と根拠

ORDレコード
ord-0749b75cb7a3407a8d78e2f757b2fc54
出典データセット
uspto-grants-1996_12
特許番号
US05580883

反応ノート

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