関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tert-Butyl hypochlorite | HCID 521297 | — |
| 反応物 | 4-Chloro-5-fluoro-2-methylpyridine | HCID 19691410 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3,4-Dichloro-5-fluoro-2-picoline | HCID 19691245 | — |
反応手順
To 0.87 g (6 mmol) of 4-chloro-5-fluoro-2-picoline, the product of Example 66, in 20 mL of chloroform cooled to -45° C., is added 0.75 mL of t-butylhypochlorite. The reaction mixture is stirred at -45° C. for 2 hours and at 0° C. for 2 hours. The reaction mixture is then poured into water and the resultant aqueous mixture is extracted with methylene chloride. The organic solution is dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure and distilled to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05580872 |
|---|
| 出典データセット | uspto-grants-1996_12 |
|---|
| ORD ID | ord-20d8845c065944d7b6c7876a6f4dfe9b |
|---|
| 出典メモ | uspto-grants-1996_12 |
|---|
