Ammonia → 2-[-(alpha-Amino-Nalpha-(benzylcarbonyl)glycinyl)amino]-benzophenone
反応式
C(S[CH:5]([C:17]([NH:19][C:20]1[CH:33]=[CH:32][CH:31]=[CH:30][C:21]=1[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:23])=[O:18])[NH:6][C:7]([O:9]CC1C=CC=CC=1)=O)(C)C.[NH3:34]>>[NH2:34][CH:5]([C:17]([NH:19][C:20]1[CH:33]=[CH:32][CH:31]=[CH:30][C:21]=1[C:22]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:23])=[O:18])[NH:6][C:7]([CH2:22][C:21]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:20]=1)=[O:9]参加物
3
実験手順
The crude product 24 (9.3 g, 20.17 mmol) was dissolved in 133 mL of dry tetrahydrafuran. This solution was saturated with ammonia at 0° C. for 30 minutes and then mercuric chloride (6 g, 22.09 mmol) was added in one portion to the stirred solution while ammonia gas was bubbled through the solution. After bubbling ammonia gas for 2 hours at 0° C. it was bubbled for an additional hour at room temperature. The suspended solids were filtered and the solvent evaporated to yield 25 (9.7 g) which was used without further purification.
後処理
- customwas bubbled through the solution
- customAfter bubbling ammonia gas for 2 hours at 0° C. it
- customwas bubbled for an additional hour at room temperature
- filtrationThe suspended solids were filtered
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-e5239504148e4eb3a00f638150a549b9
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05580979
反応ノート
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