Methanol → Methyl alpha-oxo-2-thiopheneacetate

HRID 1080709ノート

反応式

HRID 1080709 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[C:7]([OH:9])=[O:8].[CH3:11]O>CCC(CCCCC(NC(C(NC(C(NC(C(NC1C(=O)NC(CCN)C(=O)NC(CC2C=CC=CC=2)C(=O)NC(CC(C)C)C(=O)NC(CCN)C(=O)NC(CCN)C(=O)NC(C(O)C)C(=O)NCC1)=O)CCN)=O)C(O)C)=O)CCN)=O)C.OS(O)(=O)=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[C:7]([O:9][CH3:11])=[O:8]

参加物

4

反応物 2

HCID 887MethanolHCID 776942-Thiopheneglyoxylic acid

生成物 1

HCID 11217486Methyl alpha-oxo-2-thiopheneacetate

試薬・触媒・溶媒 1

HCID 5702105Aerosporin触媒

実験手順

To a stirred solution of 2-thiopheneglyoxylic acid (1 g) in methanol (10 ml) was added 5 drops of concentrated sufuric acid and the mixture was refluxed for 4 hours. Then the methanol was evaporated off and the residue was partitioned between ethyl acetate and water. The organic extract was washed with water and brine, dried (sodium sulfate) and evaporated to give methyl 2-thiopheneglyoxylate as an oil (1.01 g).

後処理

  1. temperaturethe mixture was refluxed for 4 hours
  2. customThen the methanol was evaporated off
  3. customthe residue was partitioned between ethyl acetate and water
  4. extractionThe organic extract
  5. washwas washed with water and brine
  6. dry with materialdried (sodium sulfate)
  7. customevaporated

出典と根拠

ORDレコード
ord-47a308e96fc2458889aa3190145ccd5c
出典データセット
uspto-grants-1996_12
特許番号
US05583147

反応ノート

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