2-Methylpyrrolidine → racemic [4-Amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl][3-n itro-4-(2-methyl-1-pyrrolidinyl)phenyl]methanone

HRID 10808

反応式

HRID 10808 の反応式
[NH2:1][C:2]1[N:3]=[C:4]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([N:26]3[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]3)=[CH:22][CH:21]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12](Cl)=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=1)=[O:8].[CH3:33][CH:34]1[CH2:38][CH2:37][CH2:36][NH:35]1>>[NH2:1][C:2]1[N:3]=[C:4]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([N:26]3[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]3)=[CH:22][CH:21]=2)[S:5][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([N:35]2[CH2:36][CH2:37][CH2:38][CH:34]2[CH3:33])=[C:11]([N+:16]([O-:18])=[O:17])[CH:10]=1)=[O:8]

参加物

3

反応物 2

HCID 130032-MethylpyrrolidineHCID 10162409[4-Amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl](4-chloro-3-nitrophenyl)methanone

生成物 1

HCID 21958928racemic [4-Amino-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5-thiazolyl][3-n itro-4-(2-methyl-1-pyrrolidinyl)phenyl]methanone

実験手順

This compound was prepared from the compound of Example 15 and racemic 2-methylpyrrolidine (Alfa Aesar) by the procedure used in Example 57. Mass spectrum (ES) MH+=522.

出典と根拠

ORDレコード
ord-f71ea8aaf3d74f99a567d56fac4f7b4d
出典データセット
uspto-grants-2006_08
特許番号
US07094896B2

関連ノート

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