Sodium Methoxide → 5-[1-(Methylsulfonyl)-4-piperidylthio]imidazo[1,2-a]pyridine

HRID 1081750

反応式

HRID 1081750 の反応式
[SH:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].[CH3:14][S:15]([N:18]1[CH2:23][CH2:22][CH:21](OS(C)(=O)=O)[CH2:20][CH2:19]1)(=[O:17])=[O:16]>C(O)C.CO>[CH3:14][S:15]([N:18]1[CH2:23][CH2:22][CH:21]([S:1][C:2]2[N:7]3[CH:8]=[CH:9][N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:20][CH2:19]1)(=[O:17])=[O:16]

参加物

6

反応物 3

HCID 10942334Sodium MethoxideHCID 222730651-(Methylsulfonyl)piperidin-4-yl methanesulfonateHCID 178418687HCID 178418687、化合物

生成物 1

HCID 200866605-[1-(Methylsulfonyl)-4-piperidylthio]imidazo[1,2-a]pyridine収率 40.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

To a suspension of 5-mercaptoimidazo[1,2-a]pyridine (1.50 g, 10 moles) in ethanol (100 ml) was added a solution of 4.1M sodium methylate (2.44 ml, 10 mmoles) in methanol and the mixture was stirred at room temperature for 10 minutes. To the reaction mixture was added 1-methylsulfonyl-4-methylsulfonyloxypiperidine (2.83 g, 11 mmoles) at room temperature and the mixture was heated under reflux for 14 hours. After the solvent was distilled off, the residue was dissolved in chloroform, which was washed in turn with an aqueous 1N sodium hydroxide solution and water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography [eluent:ethyl acetate/ethanol (10:1)] to obtain 1.27 g of the desired product (40.8%, light brown solid).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 14 hours
  3. distillationAfter the solvent was distilled off
  4. dissolutionthe residue was dissolved in chloroform
  5. washwhich was washed in turn with an aqueous 1N sodium hydroxide solution and water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationAfter the solvent was distilled off
  8. customthe residue was purified by column chromatography [eluent:ethyl acetate/ethanol (10:1)]

出典と根拠

ORDレコード
ord-6bf4187ea4814b69931712d96d6048e1
出典データセット
uspto-grants-1996_12
特許番号
US05587383

関連ノート

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