Sulfuric Acid → 2-(Hydroxymethyl)-4-(trifluoromethyl)phenol
反応式
COC[O:4][C:5]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][C:6]=1[CH2:7][OH:8].OS(O)(=O)=O>CO>[OH:8][CH2:7][C:6]1[CH:9]=[C:10]([C:13]([F:15])([F:16])[F:14])[CH:11]=[CH:12][C:5]=1[OH:4]参加物
4
実験手順
To the solution of 2-methoxymethoxy-5-(trifluoromethyl)benzyl alcohol (3.15 g) from Example 60 in methanol (20 ml) was added 10% H2SO4 (5 ml) for reflux under heating for 1 hour. The solvent was removed under reduced pressure. To the residue was added water, the aqueous layer was extracted with ether. The ether layer was washed with water and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, to give the title compound (2.5 g; 98%).
後処理
- temperaturefor reflux
- temperatureunder heating for 1 hour
- customThe solvent was removed under reduced pressure
- additionTo the residue was added water
- extractionthe aqueous layer was extracted with ether
- washThe ether layer was washed with water and saturated sodium chloride solution
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-d66bc06660dd4cf3b374e6e6b8b1da33
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05587392
反応ノート
読み込み中…