Imidazole → 2-Bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene
反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH2:4]O.N1C=CN=C1.[C:16]([Si:20](Cl)([CH3:22])[CH3:21])([CH3:19])([CH3:18])[CH3:17].CN(C=[O:28])C>CCOCC>[Br:1][C:2]1[C:9]([O:28][Si:20]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:22])[CH3:21])=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH3:4]参加物
6
実験手順
To the solution of 2-bromo-5-chlorobenzylalcohol (10 g) from Example 73 and imidazole (3.23 g) in dry DMF (50ml) was added dropwise t-butyl chloro dimethylsilane in dry DMF (10 ml) for 20 minutes at -0° C. After addition, the mixture was stirred for 30 minutes at room temperature. The mixture was diluted with ether, and washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate.
後処理
- additionAfter addition
- washwashed with saturated sodium chloride solution
- dry with materialdried over anhydrous sodium sulfate
出典と根拠
- ORDレコード
- ord-88b7559467854c518a0df0ac0ab495bd
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05587392
反応ノート
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