Acetone → 2,5-Difluoroanisole

HRID 1081937ノート

反応式

HRID 1081937 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[CH3:10]C(C)=O.C(=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]

参加物

6

反応物 4

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 949522,5-Difluorophenol

生成物 1

HCID 27249892,5-Difluoroanisole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

35.0 g of the product of Step A, 350 ml of acetone, 44.6 g of potassium carbonate and 40.7 g of dimethyl sulfate (neutralized on potassium bicarbonte) and was allowed to returnto ambient temperature. Water was added and extraction was carried out with ether. The extracts were washed, dried and concentrated to dryness under reduced pressure to obtain 39.8 g of the desired product.

後処理

  1. customto returnto ambient temperature
  2. extractionextraction
  3. washThe extracts were washed
  4. customdried
  5. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-119a67992fbe4cbe9939be9246da97a8
出典データセット
uspto-grants-1996_12
特許番号
US05587372

反応ノート

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