Ammonia → 4-Methoxybenzamidine Hydrochloride
反応式
[ClH:1].CO[C:4](=[NH:13])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[NH3:14]>CO>[ClH:1].[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([NH2:13])=[NH:14])=[CH:6][CH:7]=1参加物
4
実験手順
35.9 g of 4-methoxybenzimidic acid methylester hydrochloride was dissolved in 300 ml of methanol. After saturation with ammonia gas under cooling in ice-water and stirring, the solution was stirred at room temperature for 15 hours. Then, methanol was evaporated in vacuo. Ethyl acetate was added to the residue. The precipitated crystals were filtered off and dried. Whereby 30.9 g of the desired substance was obtained as white crystals. Melting point is 220° to 221° C.
後処理
- stirringthe solution was stirred at room temperature for 15 hours
- customThen, methanol was evaporated in vacuo
- additionEthyl acetate was added to the residue
- filtrationThe precipitated crystals were filtered off
- customdried
- customWhereby 30.9 g of the desired substance was obtained as white crystals
出典と根拠
- ORDレコード
- ord-3445fba12d2a4bb7b66b3f276e7d1fab
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05589477
反応ノート
読み込み中…