Ammonia → 4-Methoxybenzamidine Hydrochloride

HRID 1082081

反応式

HRID 1082081 の反応式
[ClH:1].CO[C:4](=[NH:13])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[NH3:14]>CO>[ClH:1].[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([NH2:13])=[NH:14])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 12463133Methyl 4-methoxybenzimidate hydrochloride

生成物 1

HCID 123262194-Methoxybenzamidine Hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

35.9 g of 4-methoxybenzimidic acid methylester hydrochloride was dissolved in 300 ml of methanol. After saturation with ammonia gas under cooling in ice-water and stirring, the solution was stirred at room temperature for 15 hours. Then, methanol was evaporated in vacuo. Ethyl acetate was added to the residue. The precipitated crystals were filtered off and dried. Whereby 30.9 g of the desired substance was obtained as white crystals. Melting point is 220° to 221° C.

後処理

  1. stirringthe solution was stirred at room temperature for 15 hours
  2. customThen, methanol was evaporated in vacuo
  3. additionEthyl acetate was added to the residue
  4. filtrationThe precipitated crystals were filtered off
  5. customdried
  6. customWhereby 30.9 g of the desired substance was obtained as white crystals

出典と根拠

ORDレコード
ord-3445fba12d2a4bb7b66b3f276e7d1fab
出典データセット
uspto-grants-1996_12
特許番号
US05589477

関連ノート

読み込み中…