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Dimethylformamide → 2-{6-Azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 2-{6-Chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol | HCID 11118967 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-{6-Azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol | HCID 11807790 | 87.5% |
反応手順
A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05589478 |
| 出典データセット | uspto-grants-1996_12 |
| ORD ID | ord-975e17b3c438445297449037847e6fdd |
| 出典メモ | uspto-grants-1996_12 |