2-{6-Azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol → 2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol

関与物質

反応手順

A mixture of 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g), 10% palladium-carbon (50% moist) (4.0 g) and ethanol (240 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for one hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is recrystallized from ethyl acetate/n-hexane to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (15.9 g).

情報源と証拠