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Cyanamide → {4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-hydroxy-phenyl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanamide | HCID 9864 | — |
| 反応物 | 3-Hydroxyphenacyl bromide | HCID 6917206 | — |
| 反応物 | 1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazine | HCID 21958916 | — |
| 生成物 | {4-Amino-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-hydroxy-phenyl)-methanone | HCID 21958956 | — |
反応手順
This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine (of Example 1) and 2-bromo-1-(3-hydroxyphenyl)ethanone (of Example 14N) following the procedure used in Example 24. Mass spectrum (ES) MH+=410.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094896B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-25d1fdad70a740bb8250dd9d84aad07f |
| 出典メモ | uspto-grants-2006_08 |