2-(6-Azidopyrimidin-4-yloxy)ethanol → 2-((6-Aminopyrimidin-4-yl)oxy)ethanol
反応式
[N:1]([C:4]1[N:9]=[CH:8][N:7]=[C:6]([O:10][CH2:11][CH2:12][OH:13])[CH:5]=1)=[N+]=[N-]>[C].[Pd].C(O)C>[NH2:1][C:4]1[N:9]=[CH:8][N:7]=[C:6]([O:10][CH2:11][CH2:12][OH:13])[CH:5]=1参加物
4
実験手順
A mixture of 2-(6-azidopyrimidin-4-yloxy)ethanol (1.64 g), 10% palladium-carbon (0.25 g) and ethanol (20 ml) is subjected to catalytic hydrogenation at room temperature for one hour under hydrogen atmosphere (1 atm). The catalyst is removed by filtration, and the filtrate is concentrated. The residue is recrystallized from ethanol/diethyl ether to give 2-(6-aminopyrimidin-4-yloxy)ethanol (1.11 g).
後処理
- customThe catalyst is removed by filtration
- concentrationthe filtrate is concentrated
- customThe residue is recrystallized from ethanol/diethyl ether
出典と根拠
- ORDレコード
- ord-0eb6c2ed3c334b04b66fc6a9c275e67d
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05589478
反応ノート
読み込み中…