関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Isophthalaldehyde | HCID 34777 | — |
| 反応物 | 2-Methyl-6-phenylpyridine | HCID 2762885 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 生成物 | 3-(2-(6-Phenylpyridin-2-yl)ethenyl)benzaldehyde | HCID 53953962 | — |
反応手順
A mixture of 2-methyl-6-phenylpyridine (525 mg) (step 2), isophthalaldehyde (630 mg) and dry zinc chloride (40 mg) was heated at 160° C. under N2 for 3 hours. The resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer was washed with H2O (10 cc), brine and solvent as removed in vacuo. The residue was purified by chromatography to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05004743 |
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| 出典データセット | uspto-grants-1991_04 |
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| ORD ID | ord-f283381da93346dab8a20399803753e3 |
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| 出典メモ | uspto-grants-1991_04 |
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