Triethylamine → Methyl 3-(1-naphthyl)-2-isoxazolin-5-yl(P-methyl)phosphinate

反応式

[C:1]1([CH:11]=[N:12][OH:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.ClN1C(=O)CCC1=O.[CH:22]([P:24]([CH3:28])(=[O:27])[O:25][CH3:26])=[CH2:23].C(N(CC)CC)C>>[C:1]1([C:11]2[CH2:23][CH:22]([P:24]([CH3:28])(=[O:27])[O:25][CH3:26])[O:13][N:12]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

反応物 4

HCID 8471Triethylamine

HCID 31398Chlorosuccinimide

HCID 2408011-Naphthalenecarboxaldehyde, oxime

HCID 6454580Methyl methylvinylphosphinate

生成物 1

HCID 20062396Methyl 3-(1-naphthyl)-2-isoxazolin-5-yl(P-methyl)phosphinate収率 96.8%

実験手順

39.1 g (0.25 mol) of naphthaldoxime, 36.7 g (0.275 mol) of N-chlorosuccinimide, 33 g (0.275 mol) of methyl vinyl(P-methyl)phosphinate and 38.2 ml (0.275 mol) of triethylamine are reacted as in Example 1 to give 70 g of oily product.

出典と根拠

ORDレコード: ord-f9619ce1e0f049b193c8db09d3cb2a25
出典データセット: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05006515

反応ノート

読み込み中…