化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Dimethyl 3-(4-methoxycarbonylphenyl)-2-isoxazolin-5-ylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | Dimethyl vinylphosphonate | HCID 78376 | — |
| 反応物 | Methyl 4-(hydroxyamino)benzoate | HCID 11137507 | — |
| 生成物 | Dimethyl 3-(4-methoxycarbonylphenyl)-2-isoxazolin-5-ylphosphonate | HCID 14460581 | — |
反応手順
Reaction of 80.6 g (0.45 mol) of methyl 4-hydroxyaminobenzoate, 67.0 g (0.5 mol) of N-chlorosuccinimide, 61.25 g (0.45 mol) of dimethyl vinylphosphonate and 78.45 ml (0.56 mol) of triethylamine as in Example 1 provides, after recrystallization from tert.butyl methyl ether, 115.2 g of pure product of melting point 93° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05006515 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-02d9460b3412401a8a35929ddf9a6867 |
| 出典メモ | uspto-grants-1991_04 |