Riluzole → 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide

HRID 1085126

反応式

HRID 1085126 の反応式
[OH:1][CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][C:11]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:12][C:7]=2[S:6][C:5]1=[NH:18].NC1SC2C=C(OC(F)(F)F)C=CC=2N=1.[Br:34]CCO>C(O)C>[BrH:34].[OH:1][CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][C:11]([O:13][C:14]([F:16])([F:15])[F:17])=[CH:12][C:7]=2[S:6][C:5]1=[NH:18]

参加物

5

反応物 3

HCID 5070RiluzoleHCID 108982-BromoethanolHCID 30762523-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline

生成物 1

HCID 30762513(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
20 °C

実験手順

3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline may be prepared in the following manner: 2-amino-6-trifluoromethoxybenzothiazole (9.4 g) and 2-bromoethanol (10 g) in absolute ethanol (30 cc) are heated for 95 hours to boiling. The mixture is cooled to a temperature in the region of 20° C. The precipitate formed is filtered off and washed with ethyl ether (100 cc). 3-(2-Hydroxyethyl)-2-imino-6-trifluoromethoxybenzothiazoline hydrobromide (6.4 g), m.p. 219° C., is thereby obtained.

後処理

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with ethyl ether (100 cc)

出典と根拠

ORDレコード
ord-93dd34b74fbb4f82beac53e36185ee27
出典データセット
uspto-grants-1991_04
特許番号
US05008280

関連ノート

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