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Pyridine → (-)-(1R,2S)-2-phenylcyclohexyl chloroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | rel-(1R,2S)-2-Phenylcyclohexanol | HCID 102793 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (-)-(1R,2S)-2-phenylcyclohexyl chloroacetate | HCID 14295383 | — |
反応手順
In the next step, (±)-trans-2-phenylcyclohexanol is reacted with chloroacetyl chloride at reflux in a basic solvent such as a mixture of methylene chloride and pyridine or, more preferably, 4-dimethylaminopyridine and methylene chloride. The resulting (±)-trans-2-phenylcyclohexyl chloroacetate of the formula ##STR29## can be isolated by conventional means such as extraction followed by distillation of the organic layer.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05008411 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-a3e42356f5aa4e7588e7b4d3943edfe1 |
| 出典メモ | uspto-grants-1991_04 |