Ethanol → HCID 86744734、化合物

HRID 1085464ノート

反応式

HRID 1085464 の反応式
[NH:1]([C:3]1[N:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH:10]2[CH2:12][CH2:11]2)[N:4]=1)[NH2:2].C[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O.[CH2:23](O)C>>[CH3:9][C:7]1[CH:6]=[C:5]([CH:10]2[CH2:11][CH2:12]2)[N:4]=[C:3]([NH:1][N:2]=[C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])[CH3:14])[N:8]=1

参加物

4

反応物 3

HCID 702EthanolHCID 71481-Phenyl-1-propanoneHCID 20060099HCID 20060099、化合物

生成物 1

HCID 86744734HCID 86744734、化合物

実験手順

3.3 g of 2-hydrazino-4-methyl-6-cyclopropylpyrimidine and 2.7 g of 2-methylacetophenone are heated to boiling in 40 ml of ethanol and boiled under reflux for 20 hours with stirring. The reaction solution is then cooled and the solvent is evaporated off in vacuo. For purification, the oily residue is chromatographed using hexane/ethyl acetate (2:1) over a column of silica gel.

後処理

  1. temperatureunder reflux for 20 hours
  2. temperatureThe reaction solution is then cooled
  3. customthe solvent is evaporated off in vacuo
  4. customFor purification
  5. customthe oily residue is chromatographed

出典と根拠

ORDレコード
ord-47e23cb0af584577b7e81ede76200279
出典データセット
uspto-grants-1991_04
特許番号
US05010082

反応ノート

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