Hydrochloric Acid → 6-(4-Hydroxypiperidino)carbostyril hydrochloride

HRID 1085469ノート

反応式

HRID 1085469 の反応式
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1.[ClH:19]>CO>[ClH:19].[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 104669946-(4-Hydroxypiperidino)carbostyril

生成物 1

HCID 200601536-(4-Hydroxypiperidino)carbostyril hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

6-(4-Hydroxypiperidino)carbostyril, 0.1 g (0.002 mole), was suspended in 15 mL methanol. Five mL ethanolic hydrogen chloride was added and the mixture digested on a steam bath for 15 minutes until part of the methanol had evaporated. After cooling, filtration and washing with ethyl acetate, the resulting white crystals, 0.05 g, were recrystallized by dissolving in warm methanol and adding ethyl acetate. The yield was 0.05 g 6-(4-hydroxypiperidino)carbostyril hydrochloride; m.p. 259°-262° C.

後処理

  1. customhad evaporated
  2. temperatureAfter cooling
  3. filtrationfiltration
  4. washwashing with ethyl acetate
  5. customthe resulting white crystals, 0.05 g, were recrystallized
  6. dissolutionby dissolving in warm methanol
  7. additionadding ethyl acetate

出典と根拠

ORDレコード
ord-4ca302c327e341f686b861e62fdd0b24
出典データセット
uspto-grants-1991_04
特許番号
US05010088

反応ノート

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