化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 2',5'-Dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Thiopheneacetyl chloride | HCID 162362 | — |
| 反応物 | 5'-Amino-2',5'-dideoxy-5-ethyluridine | HCID 451828 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2',5'-Dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine | HCID 54570891 | 52.8% |
反応手順
0.18 g of 2-thiopheneacetylchloride was added to a solution of 0.255 g of 5'-amino-2',5'-dideoxy-5-ethyluridine in 5 ml of water containing 1.2 ml of 1M sodium hydroxide solution and the resulting mixture was shaken vigorously for 10 minutes. The resulting white solid was collected by filtration, washed with water, dried at 50° C. in vacuo over phosphorus pentoxide and recrystallized from ethanol to give 0.2 g of 2',5'-dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine of melting point 215°-217° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05010060 |
| 出典データセット | uspto-grants-1991_04 |
| ORD ID | ord-4793037ff7474d6dbdda4aa7fcbe1ce1 |
| 出典メモ | uspto-grants-1991_04 |