Sodium Hydroxide → 2',5'-Dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine

HRID 1085539

反応式

HRID 1085539 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7](Cl)=[O:8].[NH2:10][CH2:11][C@H:12]1[O:16][C@@H:15]([N:17]2[CH:24]=[C:23]([CH2:25][CH3:26])[C:21](=[O:22])[NH:20][C:18]2=[O:19])[CH2:14][C@@H:13]1[OH:27].[OH-].[Na+]>O>[CH2:25]([C:23]1[C:21](=[O:22])[NH:20][C:18](=[O:19])[N:17]([CH:24]=1)[C@@H:15]1[O:16][C@H:12]([CH2:11][NH:10][C:7](=[O:8])[CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[C@@H:13]([OH:27])[CH2:14]1)[CH3:26]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 1623622-Thiopheneacetyl chlorideHCID 4518285'-Amino-2',5'-dideoxy-5-ethyluridine

生成物 1

HCID 545708912',5'-Dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine収率 52.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.18 g of 2-thiopheneacetylchloride was added to a solution of 0.255 g of 5'-amino-2',5'-dideoxy-5-ethyluridine in 5 ml of water containing 1.2 ml of 1M sodium hydroxide solution and the resulting mixture was shaken vigorously for 10 minutes. The resulting white solid was collected by filtration, washed with water, dried at 50° C. in vacuo over phosphorus pentoxide and recrystallized from ethanol to give 0.2 g of 2',5'-dideoxy-5-ethyl-5'-[2-(2-thienyl)acetamido]uridine of melting point 215°-217° C.

後処理

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed with water
  3. dry with materialdried at 50° C. in vacuo over phosphorus pentoxide
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-4793037ff7474d6dbdda4aa7fcbe1ce1
出典データセット
uspto-grants-1991_04
特許番号
US05010060

関連ノート

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