Hydrochloric Acid → 2-(1H-imidazol-1-ylmethyl)cyclopentanone

反応式

C1O[C:4]2([CH2:8][CH2:7][CH2:6][CH:5]2[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[O:3]C1.Cl.[OH-].[K+]>>[N:10]1([CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][C:4]2=[O:3])[CH:14]=[CH:13][N:12]=[CH:11]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 14797Potassium Hydroxide

HCID 108460442-(lH-imidazol-1-ylmethyl)cyclopentanone ethyleneketal

生成物 1

HCID 107021672-(1H-imidazol-1-ylmethyl)cyclopentanone

反応条件

温度: 60 °C

実験手順

In an oil bath, 3.5603 g of 2-(lH-imidazol-1-ylmethyl)cyclopentanone ethyleneketal (IV) and 17.8 ml of 2N hydrochloric acid added thereto were stirred at 60° C. for 5 hours. The resultant reaction solution was left cooling. Then, it was neutralized with an aqueous 1N potassium hydroxide solution and extracted with methylene chloride, to obtain an organic layer. This organic layer was washed with water, dried over anhydrous sodium sulfate, and evaporated under a reduced pressure.